Intermittent fasting has gained popularity as a method for weight loss and metabolic fitness, with new studies showing benefits beyond just physical health. A recent study published in Cell Metabolism suggests that 5:2 intermittent fasting could positively impact the brain health of older adults. The research indicates that following an intermittent fasting regimen may enhance cognitive function and overall brain health, sparking interest in exploring fasting’s potential benefits for brain function in older individuals.
The study involved 40 adults aged 55 or older with insulin resistance and healthy cognitive function. Participants were divided into two groups: the “healthy living” group following a USDA diet 7 days per week, and the intermittent fasting group replacing all meals with two shakes totaling 480 calories on two fasting days. Both groups saw overall benefits in insulin resistance and slowed brain aging, but the intermittent fasting group experienced greater improvement in memory and executive function, as well as greater weight loss.
5:2 intermittent fasting involves normal dietary intake for five days a week and restricted caloric intake for two days. The diet has been associated with weight loss, improved metabolic health, and reduced risk of chronic diseases. However, the diet may not be suitable for everyone due to challenges in adherence, potential for overeating on non-fasting days, nutrient balance concerns, risk of developing eating disorders, and unsuitability for certain individuals such as pregnant or breastfeeding women.
Despite these limitations, 5:2 intermittent fasting shows promise for supporting brain health in older adults while also aiding in weight loss. Studies have highlighted the potential benefits of this fasting regimen, making it a valuable option for those looking to improve both physical and cognitive health. However, a clinical trial published in JAMA Internal Medicine in 2017 found that when it comes to weight loss alone, alternating fasting days does not offer any significant advantage over basic calorie restriction on a daily basis. The study concluded that there was no additional benefit in terms of weight loss or weight maintenance with alternating fasting days compared to traditional calorie restriction.
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