A recent study has uncovered new insights into the immune system of patients with Alzheimer’s disease. Published in The Journal of Alzheimer’s Disease, the study is the first of its kind to describe the Th1/Th2 ratio in Alzheimer’s patients.
The study revealed that patients with moderate-to-severe Alzheimer’s disease had significantly high Th1/Th2 ratios, which had not been observed before in this patient population. When compared to healthy adults, the Alzheimer’s patients showed higher levels for all six values measured by the study authors.
After receiving a dietary supplement called a natural aloe polymannose multinutrient complex (APMC) for twelve months, the Alzheimer’s patients experienced a rebalancing of their Th1/Th2 ratio, which was associated with cognitive improvements.
The Th1/Th2 ratio refers to the balance between T Helper cells that play a crucial role in the immune system. The study suggests that maintaining a balance between the Th1 and Th2 pathways is essential for a healthy immune system.
Imbalances in the Th1/Th2 ratio have been observed in other conditions like multiple sclerosis and cancer, where the immune response tends to be either inflammatory or anti-inflammatory. Shifting the ratio towards the anti-inflammatory pathway has shown positive effects in these conditions.
The findings of this study shed light on the Th1/Th2 ratios in Alzheimer’s patients and may contribute to a better understanding of this complex disease. The study highlights the importance of maintaining a balanced immune system for overall health and well-being. This data provides us with a way to compare the pro- and anti-inflammatory elements of the immune system, aiding in a better understanding of the clinical presentation of diseases,” he stated.
In a study involving Alzheimer’s patients taking the APMC supplement, five out of six Th1/Th2 ratios shifted towards the Th2 or anti-inflammatory profile. These positive changes were linked to cognitive improvements assessed multiple times over a 12-month period.
Mr. Lewis emphasized the importance of this rebalancing in the Alzheimer’s group:
“We not only identified the Th1/Th2 ratios in Alzheimer’s patients for the first time but also demonstrated the effectiveness of the APMC dietary supplement in reducing five of the six ratios towards more balanced levels. The dominance of Th1 values offers further insight into the role of inflammation in this devastating disease. The APMC dietary supplement proves effective in altering these ratios and correlates with enhanced cognitive function.”
Dr. Judi Woolger, a co-author of the study and chief medical officer at the Agatston Center for Preventive Medicine in Miami Beach, Florida, highlighted the significance of these findings for Alzheimer’s patients, stating:
“Our research shows the importance of the interaction between major organ systems, specifically the connection between improved cognitive function and balanced immune system function, in better understanding the clinical aspects of a disease that currently lacks clarity regarding its cause and treatment. By utilizing the APMC dietary supplement, we have demonstrated the ability to enhance the quality of life for individuals in need.”
**The Role of Inflammation and Immune Dysregulation**
One factor contributing to an imbalanced immune system is uncontrolled, persistent inflammation. When the body faces an infection or injury, the initial immune response triggers short-term inflammation, necessary for healing and survival. Once the threat subsides, the inflammation should cease, and the body should return to a state of equilibrium.
Dr. Reg McDaniel, a co-author of the study and an anatomical and clinical pathologist, explained the supplement’s impact on the immune system, stating:
“The active ingredient in the APMC supplement administered to Alzheimer’s patients helped restore balance to their immune systems, bringing the Th1 and Th2 components back to homeostasis.”
When the immune system fails to regulate the inflammatory response, it can spiral out of control, leading to various health issues, including autoimmune diseases.
Although Alzheimer’s disease represents a severe case of sustained inflammation, external factors can prevent excessive inflammatory responses.
As noted by Mr. Lewis:
“These issues are exacerbated by poor diet, lack of exercise, smoking, substance abuse, sleep disturbances, stress, and other consequences of modern living. Dysregulated immune function exposes us to increased disease susceptibility, as the body’s defense mechanisms may not operate optimally. In this study, the APMC supplement serves as a valuable tool in reducing chronic inflammation in a patient population affected by a disease with a strong inflammatory component.”
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