Researchers conducted an analysis of data from over 5 million children to investigate the effects of the AstraZeneca and Pfizer-BioNTech COVID-19 vaccines on various health outcomes.
The study revealed that children who received these vaccines had an increased risk of epilepsy and appendicitis. Additionally, those who received the Pfizer vaccine were more likely to experience demyelinating disease and heart inflammation.
Dr. Julia Hippisley-Cox and her team at the University of Oxford examined data from a national database on COVID-19 vaccination and related health issues. They focused on the potential links between the vaccines and 12 outcomes, including myocarditis.
The analysis included nearly 5.2 million children, ranging from 5 to 17 years old, with data collected up to August 7, 2022.
The study found that 12 to 17-year-olds who received the Pfizer vaccine had an increased risk of myocarditis and hospitalization with epilepsy. Females in this age group also faced a higher risk of demyelinating disease after the second dose of the vaccine.
While no significant issues were identified among Moderna recipients, the study lacked statistical power due to low vaccine uptake in the UK. No elevated risks were found in 5 to 11-year-olds.
A secondary analysis confirmed the increased risk of hospitalization with epilepsy and other health issues among 12 to 17-year-olds who received the Pfizer vaccine compared to unvaccinated children. Similar risks were not observed among Moderna or AstraZeneca recipients.
The study was funded by the National Institute for Health and Care Research School for Primary Care Research. The authors disclosed conflicts of interest, including funding from vaccine manufacturers.
The authors concluded that mRNA vaccines like Pfizer and Moderna have a favorable safety profile in children and young people. However, some experts expressed concerns about potential risks associated with the vaccines.
The study’s findings highlight the importance of ongoing research to assess the safety and effectiveness of COVID-19 vaccines in children and adolescents. Please rewrite this sentence.
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