A recent analysis of 1,227 studies suggests that non-invasive herbal treatments could potentially revolutionize the way ulcerative colitis is managed. The study highlights the importance of meeting basic physiological needs like air, water, food, sleep, and warmth for overall well-being. It discusses common recommendations such as dietary changes and stress management to alleviate symptoms of ulcerative colitis.
Traditionally, the disease has been treated with anti-inflammatory drugs and surgery in severe cases. However, a new systematic review published in the journal Nutrients explores the potential of plant-derived compounds as remedies for ulcerative colitis. The analysis looked at 18 different herbs and their effectiveness in managing the condition compared to conventional drugs.
Among the herbs studied, turmeric, indigo naturalis, and Baikal skullcap showed promising results in improving clinical remission and mucosal healing in the intestine. Turmeric, specifically, has been found to have anti-inflammatory properties when administered in nano-size spheroids. Indigo naturalis, a traditional Chinese medicine, has shown efficacy in promoting mucosal healing in the gut.
Baikal skullcap, another herb used in traditional Chinese medicine, has been studied for its effects on the gut microbiota and amino acid metabolism. Research has shown that it can activate the mTOR signaling pathway, which regulates cell metabolism and growth. Additionally, Baikal skullcap has been found to normalize gut microbiota and improve the gut’s mucosal barrier.
Overall, these herbal remedies offer a potential alternative to traditional treatments for ulcerative colitis, highlighting the importance of further research and education on their use in clinical settings. Researchers found 1,542 effective targets for treating ulcerative colitis. This means that the active components of the herb work through multiple pathways to heal various aspects of the condition.
Baikal skullcap, classified as a phytopharmaceutical in Traditional Chinese Medicine, is known for its ability to clear heat, drain dampness, and resolve toxicity in the digestive tract. Licorice, another herb with roots in traditional Chinese medicine, is considered one of the most important herbs for treating ulcerative colitis.
Studies have shown that licorice promotes mitophagy, eliminates damaged organelles, and has anti-inflammatory properties that protect the digestive system. Licorice extract has been found to be effective in preclinical studies and has shown improvement in reducing inflammation and oxidative stress in animal studies.
Other herbs like Slippery Elm, Marshmallow, and Chickweed also have healing properties for ulcerative colitis. These herbs can be consumed as teas or juices to help soothe inflammation and support digestive health.
Conventional treatments for ulcerative colitis, such as corticosteroids and immunosuppressants, come with a range of side effects. These medications can cause adverse reactions like weight gain, sleep disturbances, and an increased risk of cancer. Despite their use in treating the disease, the efficacy of these drugs remains uncertain.
Food and Drug Administration Warns of Severe Adverse Drug Reactions
The Food and Drug Administration issued a warning about severe adverse drug reactions, including “serious heart-related problems and cancer.” In 2022, the agency placed a black box warning on this type of medication. The medications in question were Xeljanz and Xeljanz XR, which contain the active ingredient tofacitinib. These findings were discussed in an article in Pharmaceuticals.
However, according to the Mayo Clinic, these medications may be effective when other therapies are not successful.
Biologics
Researchers believe that an abnormal immune response may be the trigger for ulcerative colitis. Biologic therapy targets and neutralizes specific proteins in the immune system. Medications such as Infliximab, adalimumab, or golimumab are known as TNF inhibitors.
In a book listed in the National Library of Medicine, researchers explore the development of cancer malignancies, congestive heart failure, demyelinating disorder, and drug-induced lupus. Some patients have reported neurological problems and skin lesions.
A study outlined that serious liver-function abnormalities can be observed with infliximab therapy. However, the study also states that withholding these potent therapies in patients with moderate and severe forms of inflammatory bowel disease is not justifiable.
Other drugs commonly used in the treatment of ulcerative colitis include painkillers, anti-spasmodic, anti-diarrheal, and iron supplements.
It is crucial for patients to be well-informed about phytopharmaceuticals and conventional treatments so they can make informed decisions about their digestive health.
