A recent study published in Cell in April 2024 has uncovered a new mechanism linking uncontrolled blood sugar and poor diet with cancer risk. The research, conducted at the National University of Singapore’s Cancer Science Institute, found that a glucose metabolite known as Methylglyoxal (MGO) can temporarily inhibit the tumor-preventing ability of the BRCA2 protein in cells.
According to Dr. Li Ren Kong, the first author of the study, “Our study now unearthed a clue which may explain the connection between cancer risk and diet, as well as common diseases like diabetes, which arise from poor diets.”
Dr. Kong explains that MGO, a byproduct of glucose metabolism, can lead to DNA damage and inhibit the function of the BRCA2 gene, which is responsible for repairing DNA and suppressing tumor growth. This discovery highlights the impact of MGO in increasing cancer risk, especially in individuals with poor dietary habits or diabetes.
The study suggests that controlling MGO levels through diet, exercise, and medications may help reduce the risk of developing cancer, particularly in high-risk individuals with mutations in the BRCA2 gene. Further research is needed to explore the implications of these findings on cancer prevention and treatment.
Dr. Simpson, the medical director of Opt Health, emphasizes the role of lifestyle choices in cancer development, stating that every bite of food can either activate longevity genes or killer genes. The study reinforces the importance of reducing sugar intake to mitigate cancer risk and highlights the need for more research on healthy dietary choices for cancer prevention.
Dr. Simpson emphasizes the importance of consuming real food and healthy macronutrients with a low-carb intake for optimal cellular health. He advises incorporating plenty of vegetables, healthy proteins, healthy fats, as well as fish, eggs, and yogurt into one’s diet. Dr. Simpson also recommends consuming a variety of green, above-ground vegetables, some fruits, and whole foods that are minimally processed for overall well-being.
