Older adults with fluctuating cholesterol levels may benefit from engaging in preventive measures to help maintain healthy lipid levels, as stable cholesterol levels have been linked to a lower risk of dementia and cognitive decline. Fluctuations in cholesterol levels, especially without changes in medication, have been associated with a higher risk of these conditions.
Researchers believe that changes in cholesterol levels may impact atherosclerotic plaques, leading to reduced blood flow to the brain. Therefore, closer monitoring and proactive interventions may be necessary for older individuals experiencing significant fluctuations in cholesterol.
Various lifestyle practices can aid in managing cholesterol levels and potentially reducing the risk of dementia. A recent study presented at the American Heart Association’s Scientific Sessions 2024 found that high fluctuations in total cholesterol were linked to a 60% increased risk of dementia and a 23% increased risk of cognitive decline.
While fluctuations in HDL and triglycerides were not associated with dementia or cognitive decline, fluctuations in LDL and total cholesterol were linked to a more rapid decline in cognitive function. The study did not consider individuals starting or stopping lipid-lowering medications, so the findings were independent of statin use.
Cardiologists have differing opinions on the study, with some expressing concern about the impact of lipid-lowering medications on dementia risk. Lifestyle modifications, such as maintaining a healthy diet, regular exercise, and avoiding smoking, can help stabilize cholesterol levels and reduce the risk of dementia.
Future research may provide further insights into the relationship between cholesterol fluctuations and dementia risk. It is essential to aim for optimal cholesterol levels, which include low LDL cholesterol, high HDL cholesterol, and triglycerides below 150 mg/dL. Following a healthy lifestyle and managing modifiable risk factors can help stabilize cholesterol levels and promote brain health.
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